STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients
Journal article

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

  • Jerez, Andres Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
  • Clemente, Michael J. Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
  • Makishima, Hideki Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
  • Rajala, Hanna Hematology Research Unit, Department of Medicine, Division of Hematology, Helsinki University Central Hospital, Helsinki, Finland;
  • Gómez-Seguí, Ines Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
  • Olson, Thomas Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, Hershey, PA;
  • McGraw, Kathy H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;
  • Przychodzen, Bartlomiej Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
  • Kulasekararaj, Austin Department of Haematological Medicine, King's College London School of Medicine, London, United Kingdom;
  • Afable, Manuel Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
  • Husseinzadeh, Holleh D. Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
  • Hosono, Naoko Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
  • LeBlanc, Francis Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, Hershey, PA;
  • Lagström, Sonja Institute of Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; and
  • Zhang, Dan Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, Hershey, PA;
  • Ellonen, Pekka Institute of Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; and
  • Tichelli, André Clinical and Experimental Hematology, University Hospital Basel, Basel, Switzerland
  • Nissen, Catherine Clinical and Experimental Hematology, University Hospital Basel, Basel, Switzerland
  • Lichtin, Alan E. Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
  • Wodnar-Filipowicz, Aleksandra Clinical and Experimental Hematology, University Hospital Basel, Basel, Switzerland
  • Mufti, Ghulam J. Department of Haematological Medicine, King's College London School of Medicine, London, United Kingdom;
  • List, Alan F. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;
  • Mustjoki, Satu Hematology Research Unit, Department of Medicine, Division of Hematology, Helsinki University Central Hospital, Helsinki, Finland;
  • Loughran, Thomas P. Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, Hershey, PA;
  • Maciejewski, Jaroslaw P. Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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Published in:
  • Blood. - American Society of Hematology. - 2013, vol. 122, no. 14, p. 2453-2459
English Key PointsSTAT3+ T cells are found not only in detected concomitant LGL-BMFs, but in cases in which an LGL expansion was not suspected. Transformation via acquisition of a somatic mutation in T cells may be a mechanism of immune, mainly hypoplastic, bone marrow failure.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.ch/global/documents/81615
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