Journal article
STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients
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Jerez, Andres
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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Clemente, Michael J.
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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Makishima, Hideki
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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Rajala, Hanna
Hematology Research Unit, Department of Medicine, Division of Hematology, Helsinki University Central Hospital, Helsinki, Finland;
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Gómez-Seguí, Ines
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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Olson, Thomas
Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, Hershey, PA;
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McGraw, Kathy
H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;
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Przychodzen, Bartlomiej
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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Kulasekararaj, Austin
Department of Haematological Medicine, King's College London School of Medicine, London, United Kingdom;
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Afable, Manuel
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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Husseinzadeh, Holleh D.
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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Hosono, Naoko
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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LeBlanc, Francis
Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, Hershey, PA;
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Lagström, Sonja
Institute of Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; and
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Zhang, Dan
Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, Hershey, PA;
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Ellonen, Pekka
Institute of Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; and
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Tichelli, André
Clinical and Experimental Hematology, University Hospital Basel, Basel, Switzerland
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Nissen, Catherine
Clinical and Experimental Hematology, University Hospital Basel, Basel, Switzerland
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Lichtin, Alan E.
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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Wodnar-Filipowicz, Aleksandra
Clinical and Experimental Hematology, University Hospital Basel, Basel, Switzerland
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Mufti, Ghulam J.
Department of Haematological Medicine, King's College London School of Medicine, London, United Kingdom;
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List, Alan F.
H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;
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Mustjoki, Satu
Hematology Research Unit, Department of Medicine, Division of Hematology, Helsinki University Central Hospital, Helsinki, Finland;
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Loughran, Thomas P.
Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, Hershey, PA;
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Maciejewski, Jaroslaw P.
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;
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Published in:
- Blood. - American Society of Hematology. - 2013, vol. 122, no. 14, p. 2453-2459
English
Key PointsSTAT3+ T cells are found not only in detected concomitant LGL-BMFs, but in cases in which an LGL expansion was not suspected. Transformation via acquisition of a somatic mutation in T cells may be a mechanism of immune, mainly hypoplastic, bone marrow failure.
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Language
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Open access status
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green
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Identifiers
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Persistent URL
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https://sonar.ch/global/documents/81615
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