Back
Cdc37 goes beyond Hsp90 and kinases.
Journal article

Cdc37 goes beyond Hsp90 and kinases.

  • MacLean M Département de Biologie Cellulaire, Université de Genève, Sciences III, 30, quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland.
  • Picard D
  • 2003-11-25
Published in:
  • Cell stress & chaperones. - 2003
Amino Acid Sequence
Animals
Cell Cycle Proteins
Chaperonins
Drosophila Proteins
HSP90 Heat-Shock Proteins
Humans
Molecular Chaperones
Molecular Sequence Data
Protein Kinases
Protein Structure, Tertiary
Sequence Alignment
English Cdc37 is a relatively poorly conserved and yet essential molecular chaperone. It has long been thought to function primarily as an accessory factor for Hsp90, notably directing Hsp90 to kinases as substrates. More recent discoveries challenge this simplistic view. Cdc37 client proteins other than kinases have now been found, and Cdc37 displays a variety of Hsp90-independent activities both in vitro and in vivo. It can function as a molecular chaperone by itself, interact with other Hsp90 cochaperones in the absence of Hsp90, and even support yeast growth and protein folding without its Hsp90-binding domain. Thus, for many substrates, there may be many alternative chaperone pathways involving Cdc37, Hsp90, or both.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/82760
Statistics
Document views: 23 File downloads: