![Quality assurance and quality control methods for animal and human applications of no-carrier-added 6-[18F]fluorodopa for PET investigations of dopaminergic systems.](/static/images/no-image.png)
Journal article
Quality assurance and quality control methods for animal and human applications of no-carrier-added 6-[18F]fluorodopa for PET investigations of dopaminergic systems.
- Reddy GN Division of Radiopharmacy, Paul Scherrer Institute, Villigen PSI, Switzerland.
- Haeberli M
- Beer HF
- Hasler P
- Schubiger AP
- 1993-07-01
Published in:
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. - 1993
Animals
Dihydroxyphenylalanine
Fluorine Radioisotopes
Humans
Quality Assurance, Health Care
Quality Control
Tomography, X-Ray Computed
English
No-Carrier-Added (NCA) 6-[18F]fluoro-L-dopa (6-FDOPA) is being produced routinely for PET investigations of dopaminergic systems at our Institute. We describe here in detail the quality assurance methods involved in its multi-step developmental stage as a radiopharmaceutical. A method to remove toxic copper ions to prepare an injectable solution is described. The stability and shelf-life of NCA 6-FDOPA was also examined and results are discussed. Quality control involved three major aspects: (a) chemical purity, (b) radiochemical purity and (c) enantiomeric excess. A method for quick quality control of individual batch preparations is described.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/0969-8043(93)90001-q
- PMID 8339075
- Persistent URL
- https://sonar.ch/global/documents/83180
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