Tracking the evolution of cancer methylomes.

Krebs AR; Schübeler D

doi:10.1038/ng.2451

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Journal article

Tracking the evolution of cancer methylomes.

Krebs AR Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Schübeler D

2012-10-30

Published in:

Nature genetics. - 2012

English Cellular transformation in cancer has long been associated with aberrant DNA methylation, most notably, hypermethylation of promoter sequences. A new study uses a clever approach of selective high-resolution profiling to follow DNA methylation over a time course of cellular transformation and challenges the notion that hypermethylation in cancer arises in an orchestrated fashion.

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