Journal article

Genome-wide association study identifies 30 loci associated with bipolar disorder.

  • Stahl EA Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eli.stahl@mssm.edu.
  • Breen G MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
  • Forstner AJ Department of Biomedicine, University of Basel, Basel, Switzerland.
  • McQuillin A Division of Psychiatry, University College London, London, UK.
  • Ripke S Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Trubetskoy V Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
  • Mattheisen M iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
  • Wang Y Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, Denmark.
  • Coleman JRI MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
  • Gaspar HA MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
  • de Leeuw CA Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
  • Steinberg S deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Pavlides JMW Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
  • Trzaskowski M Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  • Byrne EM Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  • Pers TH Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Holmans PA Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Richards AL Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Abbott L Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Agerbo E iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Akil H Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
  • Albani D Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
  • Alliey-Rodriguez N Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
  • Als TD iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
  • Anjorin A Department of Psychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, UK.
  • Antilla V Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Awasthi S Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
  • Badner JA Department of Psychiatry, Rush University Medical Center, Chicago, IL, USA.
  • Bækvad-Hansen M iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Barchas JD Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
  • Bass N Division of Psychiatry, University College London, London, UK.
  • Bauer M Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Belliveau R Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Bergen SE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Pedersen CB iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Bøen E Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
  • Boks MP Psychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, the Netherlands.
  • Boocock J Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Budde M Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
  • Bunney W Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
  • Burmeister M Molecular & Behavioral Neuroscience Institute and Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
  • Bybjerg-Grauholm J iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Byerley W Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
  • Casas M Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
  • Cerrato F Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Cervantes P Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, Quebec, Canada.
  • Chambert K Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Charney AW Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Chen D Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Churchhouse C Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Clarke TK Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland.
  • Coryell W University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
  • Craig DW Translational Genomics, USC, Phoenix, AZ, USA.
  • Cruceanu C Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, Quebec, Canada.
  • Curtis D Centre for Psychiatry, Queen Mary University of London, London, UK.
  • Czerski PM Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
  • Dale AM Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • de Jong S MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
  • Degenhardt F Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
  • Del-Favero J Applied Molecular Genomics Unit, VIB Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium.
  • DePaulo JR Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Djurovic S Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway.
  • Dobbyn AL Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Dumont A Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Elvsåshagen T Department of Neurology, Oslo University Hospital, Oslo, Norway.
  • Escott-Price V Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Fan CC Department of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.
  • Fischer SB Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Flickinger M Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
  • Foroud TM Department of Medical & Molecular Genetics, Indiana University, Indianapolis, IN, USA.
  • Forty L Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Frank J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Fraser C Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Freimer NB Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Frisén L Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Gade K Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
  • Gage D Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Garnham J Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Giambartolomei C Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Pedersen MG iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Goldstein J Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Gordon SD Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Gordon-Smith K Department of Psychological Medicine, University of Worcester, Worcester, UK.
  • Green EK School of Biomedical Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry, University of Plymouth, Plymouth, UK.
  • Green MJ School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
  • Greenwood TA Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Grove J iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
  • Guan W Biostatistics, University of Minnesota System, Minneapolis, MN, USA.
  • Guzman-Parra J Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
  • Hamshere ML Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Hautzinger M Department of Psychology, Eberhard Karls Universität Tübingen, Tubingen, Germany.
  • Heilbronner U Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
  • Herms S Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Hipolito M Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
  • Hoffmann P Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Holland D Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Huckins L Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Jamain S Psychiatrie Translationnelle, Inserm U955, Créteil, France.
  • Johnson JS Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Juréus A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Kandaswamy R MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
  • Karlsson R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Kennedy JL Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Onatario, Canada.
  • Kittel-Schneider S Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
  • Knowles JA Cell Biology, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
  • Kogevinas M ISGlobal, Barcelona, Spain.
  • Koller AC Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
  • Kupka R Psychiatry, Altrecht, Utrecht, the Netherlands.
  • Lavebratt C Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Lawrence J Department of, rth East London NHS Foundation Trust, Ilford, UK.
  • Lawson WB Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
  • Leber M Department of Neurodegenerative Diseases and Geropsychiatry, University Hospital Bonn, Bonn, Germany.
  • Lee PH Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Levy SE HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
  • Li JZ Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Liu C Department of Psychiatry, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
  • Lucae S Max Planck Institute of Psychiatry, Munich, Germany.
  • Maaser A Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
  • MacIntyre DJ Mental Health, NHS 24, Glasgow, UK.
  • Mahon PB Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Maier W Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
  • Martinsson L Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • McCarroll S Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • McGuffin P MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
  • McInnis MG Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
  • McKay JD Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France.
  • Medeiros H Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
  • Medland SE Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Meng F Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
  • Milani L Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Montgomery GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  • Morris DW Discipline of Biochemistry, Neuroimaging and Cognitive Genomics (NICOG) Centre, National University of Ireland, Galway, Galway, Ireland.
  • Mühleisen TW Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Mullins N MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
  • Nguyen H Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Nievergelt CM Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Adolfsson AN Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden.
  • Nwulia EA Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
  • O'Donovan C Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Loohuis LMO Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Ori APS Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
  • Oruc L Department of Clinical Psychiatry, Psychiatry Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
  • Ösby U Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Perlis RH Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
  • Perry A Department of Psychological Medicine, University of Worcester, Worcester, UK.
  • Pfennig A Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Potash JB Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Purcell SM Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Regeer EJ Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, the Netherlands.
  • Reif A Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
  • Reinbold CS Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Rice JP Department of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA.
  • Rivas F Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
  • Rivera M MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
  • Roussos P Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Ruderfer DM Medicine, Psychiatry, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Ryu E Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Sánchez-Mora C Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
  • Schatzberg AF Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Scheftner WA Rush University Medical Center, Chicago, IL, USA.
  • Schork NJ Scripps Translational Science Institute, La Jolla, CA, USA.
  • Shannon Weickert C School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
  • Shehktman T Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Shilling PD Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Sigurdsson E Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
  • Slaney C Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Smeland OB Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Sobell JL Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
  • Søholm Hansen C iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Spijker AT Mood Disorders, PsyQ, Rotterdam, the Netherlands.
  • St Clair D Institute for Medical Sciences, University of Aberdeen, Aberdeen, UK.
  • Steffens M Research Division, Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany.
  • Strauss JS Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Streit F Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Strohmaier J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Szelinger S Neurogenomics, TGen, Phoenix, AZ, USA.
  • Thompson RC Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
  • Thorgeirsson TE deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Treutlein J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Vedder H Department of Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany.
  • Wang W Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Watson SJ Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
  • Weickert TW School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
  • Witt SH Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Xi S Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA.
  • Xu W Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, Onatario, Canada.
  • Young AH Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Zandi P Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
  • Zhang P Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Zöllner S Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
  • Adolfsson R Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Agartz I Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Alda M Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
  • Backlund L Department of Psychiatry and Addiction Medicine, Assistance Publique-Hopitaux de Paris, Paris, France.
  • Baune BT Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
  • Bellivier F Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Berrettini WH Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland.
  • Biernacka JM Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
  • Blackwood DHR iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
  • Boehnke M Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Børglum AD Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Corvin A Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Craddock N Department of Psychiatry, University of Munster, Munster, Germany.
  • Daly MJ Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Dannlowski U Department of Psychiatry and Addiction Medicine, Assistance Publique-Hopitaux de Paris, Paris, France.
  • Esko T Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
  • Etain B Neuroscience Research Australia, Sydney, New South Wales, Australia.
  • Frye M Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
  • Fullerton JM Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Gershon ES Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Gill M Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
  • Goes F Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
  • Grigoroiu-Serbanescu M iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Hauser J Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Hougaard DM Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Hultman CM Department of Psychological Medicine, University of Worcester, Worcester, UK.
  • Jones I Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Jones LA Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Kahn RS Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Kirov G Faculté de Médecine, Université Paris Est, Créteil, France.
  • Landén M MRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
  • Leboyer M Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA.
  • Lewis CM Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
  • Li QS Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Lissowska J Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
  • Martin NG Research Institute, Lindner Center of HOPE, Mason, OH, USA.
  • Mayoral F Division of Psychiatry, University of Edinburgh, Edinburgh, Scotland.
  • McElroy SL Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
  • McIntosh AM Division of Mental Health and Addiction and Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.
  • McMahon FJ Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Melle I School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
  • Metspalu A Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology-NTNU, Trondheim, Norway.
  • Mitchell PB iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Morken G iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
  • Mors O Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
  • Mortensen PB HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
  • Müller-Myhsok B Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
  • Myers RM Psychiatry and Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
  • Neale BM iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Nimgaonkar V Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
  • Nordentoft M Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Nöthen MM Division of Psychiatry, Haukeland Universitetssjukehus, Bergen, Norway.
  • O'Donovan MC Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Oedegaard KJ Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA.
  • Owen MJ Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
  • Paciga SA Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
  • Pato C Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
  • Pato MT Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
  • Posthuma D Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
  • Ramos-Quiroga JA Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Ribasés M Department of Neurology and Neurosurgery, McGill University, Faculty of Medicine, Montreal, Quebec, Canada.
  • Rietschel M Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Rouleau GA Neuroscience Research Australia, Sydney, New South Wales, Australia.
  • Schalling M Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
  • Schofield PR Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
  • Schulze TG Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
  • Serretti A deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Smoller JW deCODE Genetics/Amgen, Reykjavik, Iceland.
  • Stefansson H Department of Psychiatry, Hospital Namsos, Namsos, Norway.
  • Stefansson K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Stordal E Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
  • Sullivan PF Department of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway.
  • Turecki G Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
  • Vaaler AE Centre for Addiction and Mental Health, Toronto, Onatario, Canada.
  • Vieta E iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
  • Vincent JB Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Werge T Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
  • Nurnberger JI Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
  • Wray NR Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Di Florio A Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Edenberg HJ Psychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, the Netherlands.
  • Cichon S Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
  • Ophoff RA Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Scott LJ Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. jkelsoe@ucsd.edu.
  • Andreassen OA Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kelsoe J
  • Sklar P
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  • 2019-05-03
Published in:
  • Nature genetics. - 2019
English Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10-8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.
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https://sonar.ch/global/documents/84436
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