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Apoptosis in the estrous and menstrual cycles.
Journal article

Apoptosis in the estrous and menstrual cycles.

  • Andres AC Department of Clinical Research, University of Berne, Switzerland. andres@dkf3.unibe.ch
  • Strange R
  • 1999-07-30
Published in:
  • Journal of mammary gland biology and neoplasia. - 1999
Animals
Apoptosis
Estrus
Female
Genes, Homeobox
Genes, bcl-2
Humans
Menstrual Cycle
Multigene Family
Pregnancy
Protein-Tyrosine Kinases
English In the absence of pregnancy, the adult mammary gland is subjected to cyclic fluctuations of hormonal stimulation that constitute the estrous and menstrual cycles. The mammary epithelium responds to these systemic hormonal changes by regional proliferation, differentiation and cell death by apoptosis. The fact that the mammary epithelial response involves only a minor subset of the epithelial cells implies a delicate local control of epithelial cell fate resulting in either cell death or survival. Evidence gleaned from descriptive data suggests that the apoptosis-related genes of the Bcl-2 gene family, tissue remodeling genes, protein tyrosine kinases and master genes of the homeotic gene cluster may be involved in determining epithelial cell fate during the estrous cycle.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/8455
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