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Mismatch repair defects in cancer.
Journal article

Mismatch repair defects in cancer.

  • Jiricny J Institute of Medical Radiobiology of the University of Zürich, Paul Scherrer Institute, Zürich, CH-8008, Switzerland. jiricny@imr.unizh. ch
  • Nyström-Lahti M
  • 2000-04-08
Published in:
  • Current opinion in genetics & development. - 2000
Animals
Base Pair Mismatch
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
Humans
English Post-replicative mismatch repair in humans utilises the hMSH2, hMSH6, hMSH3, hMLH1 and hPMS2 genes and possibly the newly identified hMLH3 gene. Recently, a link has been established between hMSH6 mutations and 'atypical' hereditary non-polyposis colon cancer (HNPCC) with an increased incidence of endometrial cancers. To satisfy the need for a diagnostic test capable of differentiating between pathogenic mutations and polymorphisms, several functional assays that fulfil these criteria have been described. These should allow for better diagnosis of HNPCC.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/84794
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