Back
Genetic diversity in Mycobacterium tuberculosis.
Journal article

Genetic diversity in Mycobacterium tuberculosis.

  • Gagneux S Swiss Tropical and Public Health Institute (Swiss TPH), University of Basel, Basel, Switzerland, Sebastien.Gagneux@unibas.ch.
  • 2013-05-17
Published in:
  • Current topics in microbiology and immunology. - 2013
Genes, Bacterial
Genetic Variation
Genome, Bacterial
High-Throughput Nucleotide Sequencing
Host-Pathogen Interactions
Humans
Mycobacterium tuberculosis
Phylogeny
Phylogeography
Tuberculosis, Pulmonary
Virulence
English Recent years have witnessed an increased appreciation of the extent and relevance of strain-to-strain variation in Mycobacterium tuberculosis. This paradigm shift can largely be attributed to an improved understanding of the global population structure of this organism, and to the realisation that the various members of the M. tuberculosis complex (MTBC) harbour more genetic diversity than previously realised. Moreover, many studies using experimental models of infection have demonstrated that MTBC diversity translates into significant differences in immunogenecity and virulence . However, linking these experimental phenotypes to relevant clinical phenotypes has been difficult, and to date, largely unsuccessful. Nevertheless, emerging high-throughput technologies, in particular next-generation sequencing , offer new opportunities, and have already lead to important new insights. Given the complexity of the host-pathogen interaction in tuberculosis, systems approaches will be key to define the role of MTBC diversity in the fight against one of humankind's most important pathogens.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/8521
Statistics
Document views: 47 File downloads: