Back
Perinatal and neonatal use of paracetamol for pain relief.
Journal article

Perinatal and neonatal use of paracetamol for pain relief.

  • Allegaert K Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Intensive Care and Department of Pediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands. Electronic address: karel.allegaert@uzleuven.be.
  • van den Anker JN Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands; Division of Clinical Pharmacology, Department of Pediatrics, Children's National Health System, Washington DC, USA; Division of Paediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.
  • 2017-07-20
Published in:
  • Seminars in fetal & neonatal medicine. - 2017
Breastfeeding
Newborn
Pain
Paracetamol
Safety
Target effect concentration
Acetaminophen
Analgesics, Non-Narcotic
Female
Humans
Infant, Newborn
Pain
Pain Management
Pregnancy
English Paracetamol (acetaminophen) is the most widely used drug to treat pain or fever in pregnant women or neonates, but its pharmacokinetics (PK) and pharmacodynamics (PD) warrant a focused analysis. During pregnancy, there is an important increase in paracetamol clearance. Consequently, it is reasonable to anticipate that the analgesic effect of paracetamol will decrease faster, whereas higher doses may result in even higher oxidative toxic metabolites. Therefore, most peripartal PD data relate to multimodal analgesia strategies. In neonates, weight/size is the most relevant covariate of paracetamol PK. This resulted in proposed dosing regimens containing higher doses than currently prescribed in the label for term neonates. Using adequate dosing, paracetamol is a poor procedural analgesic, is effective for mild-to-moderate pain, and has morphine-sparing effects. Short-term safety has been well documented, and there is active research investigating the potential association between paracetamol exposure and atopy, fertility, and neurobehavior.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/8986
Statistics
Document views: 32 File downloads: