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Etomidate--a review of robust evidence for its use in various clinical scenarios.
Journal article

Etomidate--a review of robust evidence for its use in various clinical scenarios.

  • 2014-03-05
Published in:
  • Acta anaesthesiologica Scandinavica. - 2014
Anesthesia, General
Anesthesia, Intravenous
Anesthetics, Intravenous
Cardiovascular Diseases
Conscious Sedation
Etomidate
Humans
Hypnotics and Sedatives
Hypotension
Risk Assessment
Sepsis
English Etomidate is an intravenous hypnotic with a favourable clinical profile in haemodynamic high-risk scenarios. Currently, there is an active debate about the clinical significance of the drug's side effects and its overall risk-benefit ratio. Etomidate-induced transient adrenocortical suppression is well documented and has been associated with increased mortality in sepsis. In surgical patients at risk of hypotensive complications, however, a review of current literature provides no robust evidence to contraindicate a single-bolus etomidate induction. Large randomised controlled trials as well as additional observational data are required to compare safety of etomidate and its alternatives.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/89990
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