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Pleiotropic effects of oxidized phospholipids.
Journal article

Pleiotropic effects of oxidized phospholipids.

  • Bochkov V Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Austria. Electronic address: valery.bochkov@uni-graz.at.
  • Gesslbauer B Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Austria.
  • Mauerhofer C Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Austria.
  • Philippova M Signaling Laboratory, Department of Biomedicine, Basel University Hospital, Basel, Switzerland.
  • Erne P Signaling Laboratory, Department of Biomedicine, Basel University Hospital, Basel, Switzerland.
  • Oskolkova OV Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Austria. Electronic address: o.oskolkova@uni-graz.at.
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  • 2016-12-29
Published in:
  • Free radical biology & medicine. - 2017
Analytics of oxidized phospholipids
Biological activities
Oxidized phospholipids
Receptors of oxidized phospholipids
Animals
Atherosclerosis
Biomarkers
Endothelium
Gene Expression Regulation
Humans
Immune Tolerance
Inflammation
Neovascularization, Pathologic
Oxidation-Reduction
Permeability
Phospholipids
Receptors, Lysophospholipid
Thrombosis
English Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of normal and pathological states. OxPLs were implicated in regulation of inflammation, thrombosis, angiogenesis, endothelial barrier function, immune tolerance and other important processes. Rapidly accumulating evidence suggests that OxPLs are biomarkers of atherosclerosis and other pathologies. In addition, successful application of experimental drugs based on structural scaffold of OxPLs in animal models of inflammation was recently reported. This review briefly summarizes current knowledge on generation, methods of quantification and biological activities of OxPLs. Furthermore, receptor and cellular mechanisms of these effects are discussed. The goal of the review is to give a broad overview of this class of lipid mediators inducing pleiotropic biological effects.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/90687
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