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The ameliorative effects of boron against acrylamide-induced oxidative stress, inflammatory response, and metabolic changes in rats.
Journal article

The ameliorative effects of boron against acrylamide-induced oxidative stress, inflammatory response, and metabolic changes in rats.

  • Acaroz U Afyon Kocatepe University, Veterinary Faculty, Department of Food Hygiene and Technology, Afyonkarahisar, Turkey. Electronic address: ulasacaroz@aku.edu.tr.
  • Ince S Afyon Kocatepe University, Veterinary Faculty, Department of Pharmacology and Toxicology, Afyonkarahisar, Turkey.
  • Arslan-Acaroz D Afyon Kocatepe University, Bayat Vocational School, Afyonkarahisar, Turkey.
  • Gurler Z Afyon Kocatepe University, Veterinary Faculty, Department of Food Hygiene and Technology, Afyonkarahisar, Turkey.
  • Kucukkurt I Afyon Kocatepe University, Veterinary Faculty, Department of Biochemistry, Afyonkarahisar, Turkey.
  • Demirel HH Afyon Kocatepe University, Bayat Vocational School, Afyonkarahisar, Turkey.
  • Arslan HO University of Zurich, Vetsuisse Faculty, Clinic of Reproductive Medicine, Switzerland.
  • Varol N Afyon Kocatepe University, Faculty of Medicine, Department of Medical Genetics, 03200 Afyonkarahisar, Turkey.
  • Zhu K China Agricultural University, College of Veterinary Medicine, Beijing, National Center for Veterinary Drug Safety Evaluation, 100193, China.
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  • 2018-06-19
Published in:
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. - 2018
Acrylamide
Boron
Gene expression
Histopathology
Oxidative stress
Rat
Acrylamide
Animal Feed
Animals
Antioxidants
Boron
Catalase
Gene Expression
Glutathione
Inflammation
Lipid Peroxidation
Male
Oxidative Stress
Rats, Wistar
Superoxide Dismutase
English Acrylamide (ACR) is a hazardous substance associated with the accumulation of excessive reactive oxygen species and causes oxidative stress. Presence of ACR in foods leads to public health concerns due to its known neurotoxic, genotoxic, and carcinogenic effects. The present study investigated the ameliorative effects of boron (B) against ACR exposed rats. Forty Wistar albino male rats, fed with low-boron diet, were randomly and equally allocated into 5 groups. The control group was orally treated with physiological saline as placebo, the second group was orally given 15 mg/kg ACR. The other groups were orally treated with 15 mg/kg ACR and B at the levels of 5, 10, and 20 mg/kg/day for 60 days, respectively. ACR-treatment significantly increased malondialdehyde levels whereas decreased glutathione levels in rat tissues. Also, ACR-treatment increased the activities of superoxide dismutase and catalase in erythrocytes and tissues. Meanwhile, mRNA expression levels of NFĸB, IFN-γ, IL-1β, and TNF-α in liver and brain of rats were increased under ACR treatment. Additionally, ACR caused a significant decrease in the level of high-density lipoprotein, with increase in the levels of low-density lipoprotein, triglyceride, cholesterol, glucose, urea nitrogen, and creatinine. Lastly, B alleviated histopathological alterations induced by ACR in rat tissues.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/91259
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