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Structure–Activity-Relationship Studies around the 2-Amino Group and Pyridine Core of Antimalarial 3,5-Diarylaminopyridines Lead to a Novel Series of Pyrazine Analogues with Oral in Vivo Activity
Journal article

Structure–Activity-Relationship Studies around the 2-Amino Group and Pyridine Core of Antimalarial 3,5-Diarylaminopyridines Lead to a Novel Series of Pyrazine Analogues with Oral in Vivo Activity

  • Younis, Yassir Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
  • Douelle, Frederic Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
  • González Cabrera, Diego Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
  • Le Manach, Claire Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
  • Nchinda, Aloysius T. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
  • Paquet, Tanya Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
  • Street, Leslie J. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
  • White, Karen L. Centre for Drug Candidate Optimisation, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia
  • Zabiulla, K. Mohammed Syngene International Ltd., Biocon Park, Plot No. 2 & 3. Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India
  • Joseph, Jayan T. Syngene International Ltd., Biocon Park, Plot No. 2 & 3. Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India
  • Bashyam, Sridevi Syngene International Ltd., Biocon Park, Plot No. 2 & 3. Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India
  • Waterson, David Medicines for Malaria Venture, ICC Building, Route de Pré-Bois 20, P.O. Box 1826, 1215 Geneva, Switzerland
  • Witty, Michael J. Medicines for Malaria Venture, ICC Building, Route de Pré-Bois 20, P.O. Box 1826, 1215 Geneva, Switzerland
  • Wittlin, Sergio University of Basel, Socinstrasse 57, 4002 Basel, Switzerland
  • Charman, Susan A. Centre for Drug Candidate Optimisation, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia
  • Chibale, Kelly Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa
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  • 2013-10-29
Published in:
  • Journal of Medicinal Chemistry. - American Chemical Society (ACS). - 2013, vol. 56, no. 21, p. 8860-8871
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/92566
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