Physiological roles of PKB/Akt isoforms in development and disease
- Dummler, B. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
- Hemmings, B.A. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
- 2007-3-20
Published in:
- Biochemical Society Transactions. - Portland Press Ltd.. - 2007, vol. 35, no. 2, p. 231-235
English
PKB (protein kinase B, also known as Akt) is a serine/threonine protein kinase that is important in various signalling cascades and acts as a major signal transducer downstream of activated phosphoinositide 3-kinase. There are three closely related isoforms of PKB in mammalian cells, PKBα (Akt1), PKBβ (Akt2) and PKBγ (Akt3), and this review discusses recent advances in our understanding of the functions of these isoforms in the regulation of adipocyte differentiation, glucose homoeostasis and tumour development.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1042/bst0350231
- ISSN 0300-5127
- Persistent URL
- https://sonar.ch/global/documents/92689
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