Journal article
Contribution of major cardiovascular risk factors to familial premature coronary artery disease: the GENECARD project.
- Jomini V Department of Medicine, CHUV University Hospital, Lausanne, Switzerland.
- Oppliger-Pasquali S
- Wietlisbach V
- Rodondi N
- Jotterand V
- Paccaud F
- Darioli R
- Nicod P
- Mooser V
- 2002-09-03
Published in:
- Journal of the American College of Cardiology. - 2002
Adult
Age of Onset
Cardiovascular Diseases
Coronary Disease
Female
Humans
Hypercholesterolemia
Hypertension
Male
Middle Aged
Myocardial Infarction
Obesity
Pedigree
Prevalence
Risk Factors
Smoking
English
OBJECTIVES
This study was designed to assess the prevalence of major cardiovascular risk factors in familial premature coronary artery disease (P-CAD), affecting two or more siblings within one sibship.
BACKGROUND
Premature CAD has a genetic component. It remains to be established whether familial P-CAD is due to genes acting independently from major cardiovascular risk factors.
METHODS
We recruited 213 P-CAD survivors from 103 sibships diagnosed before age
RESULTS
Compared with the general population, patients with sporadic P-CAD had a higher prevalence of hypertension (29% vs. 14%, p < 0.001), hypercholesterolemia (54% vs. 33%, p < 0.001), obesity (20% vs. 13%, p < 0.01), and smoking (76% vs. 39%, p < 0.001). These risk factors were equally or even more prevalent in patients with familial P-CAD (43% [p < 0.05 vs. sporadic P-CAD], 58% [p = 0.07], 21% and 72%, respectively). Overall, only 7 (4%) of 163 of patients with familial P-CAD and 22 (7%) of 326 of patients with sporadic P-CAD had none of these conditions, as compared with 167 (34%) of 489 patients in the general population.
CONCLUSIONS
Classic, remediable risk factors are highly prevalent in patients with familial P-CAD. Accordingly, a major contribution of genes acting in the absence of these risk factors is unlikely.
This study was designed to assess the prevalence of major cardiovascular risk factors in familial premature coronary artery disease (P-CAD), affecting two or more siblings within one sibship.
BACKGROUND
Premature CAD has a genetic component. It remains to be established whether familial P-CAD is due to genes acting independently from major cardiovascular risk factors.
METHODS
We recruited 213 P-CAD survivors from 103 sibships diagnosed before age
RESULTS
Compared with the general population, patients with sporadic P-CAD had a higher prevalence of hypertension (29% vs. 14%, p < 0.001), hypercholesterolemia (54% vs. 33%, p < 0.001), obesity (20% vs. 13%, p < 0.01), and smoking (76% vs. 39%, p < 0.001). These risk factors were equally or even more prevalent in patients with familial P-CAD (43% [p < 0.05 vs. sporadic P-CAD], 58% [p = 0.07], 21% and 72%, respectively). Overall, only 7 (4%) of 163 of patients with familial P-CAD and 22 (7%) of 326 of patients with sporadic P-CAD had none of these conditions, as compared with 167 (34%) of 489 patients in the general population.
CONCLUSIONS
Classic, remediable risk factors are highly prevalent in patients with familial P-CAD. Accordingly, a major contribution of genes acting in the absence of these risk factors is unlikely.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/s0735-1097(02)02017-x
- PMID 12204497
- Persistent URL
- https://sonar.ch/global/documents/93602
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