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Lupus-like syndrome associated with statin therapy.
Journal article

Lupus-like syndrome associated with statin therapy.

  • Noël B Department of Dermatology, Centre Hospitalier Universitaire Vaudois (DHURDV), Lausanne, Switzerland. bernard.noel@chuv.hospvd.ch
  • Panizzon RG
  • 2004-05-01
Published in:
  • Dermatology (Basel, Switzerland). - 2004
Antibodies, Antinuclear
DNA
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypercholesterolemia
Lupus Erythematosus, Systemic
Male
Middle Aged
Simvastatin
English Statins are among the most widely prescribed drugs. An increasing number of lupus-like syndrome has recently been reported with these lipid-lowering agents. We describe a new case associated with simvastatin therapy. The presence of anti-dsDNA antibodies in the serum is for the first time reported confirming that statins may also induce a systemic autoimmune reaction. Statin-induced lupus-like syndrome is characterized by the long delay between the beginning of therapy and the skin eruption. Antinuclear antibodies may persist for many months after drug discontinuation. The causal relationship may be therefore difficult to establish, and probably many cases are unrecognized. Early diagnosis may avoid unnecessary immunosuppressive therapy.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/93701
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