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Nuclear triiodothyronine receptor expression is regulated by axon-Schwann cell contact.
Journal article

Nuclear triiodothyronine receptor expression is regulated by axon-Schwann cell contact.

  • Walter IB Institut d'Histologie et d'Embryologie, Faculté de Médecine, Université de Lausanne, Switzerland.
  • 1993-11-18
Published in:
  • Neuroreport. - 1993
Animals
Animals, Newborn
Axons
Cell Communication
Cell Nucleus
Ganglia, Spinal
Nerve Regeneration
Organ Culture Techniques
Rats
Rats, Wistar
Receptors, Thyroid Hormone
Schwann Cells
Sciatic Nerve
Triiodothyronine
Up-Regulation
English Thyroid hormones, which play an important role in the development and regeneration of the nervous system, require the presence of specific nuclear T3 receptors (NT3R). In this study we provide evidence that NT3R expression by Schwann cells was up-regulated in response to a loss of axonal contact in vitro and in vivo. In dorsal root ganglia explant cultures, Schwann cells which accompanied axons (nerve fibres) were devoid of NT3R. When Schwann cells were orphaned from axon contact by axon transection, all the nuclei of these cells displayed NT3R immunoreactivity. Similar results were obtained in situ; in adult rat sciatic nerve, Schwann cells which ensheathed healthy axons never expressed NT3R immunoreactivity. After sciatic nerve transection in vivo the nuclei of Schwann cells deprived of axonal contact displayed a clear NT3R immunoreaction.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/93719
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