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Gallery Game: Smartphone-based assessment of long-term memory in adults at risk of Alzheimer's disease.
Journal article

Gallery Game: Smartphone-based assessment of long-term memory in adults at risk of Alzheimer's disease.

  • Lancaster C Big Data Institute, University of Oxford, Oxford, UK.
  • Koychev I Department of Psychiatry, University of Oxford, Oxford, UK.
  • Blane J Department of Psychiatry, University of Oxford, Oxford, UK.
  • Chinner A Department of Psychiatry, University of Oxford, Oxford, UK.
  • Chatham C Roche Innovation Centre, F.Hoffmann-La Roche Ltd., Basel, Switzerland.
  • Taylor K Roche Innovation Centre, F.Hoffmann-La Roche Ltd., Basel, Switzerland.
  • Hinds C Big Data Institute, University of Oxford, Oxford, UK.
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  • 2020-01-25
Published in:
  • Journal of clinical and experimental neuropsychology. - 2020
Alzheimer’s disease
cognitive assessment
digital technology
episodic memory
perirhinal cortex
English Introduction: Gallery Game, deployed within the Mezurio smartphone app, targets the processes of episodic memory hypothesized to be first vulnerable to neurofibrillary tau-related degeneration in Alzheimer's Disease, prioritizing both perirhinal and entorhinal cortex/hippocampal demands.Methods: Thirty-five healthy adults (aged 40-59 years), biased toward those at elevated familial risk of dementia, completed daily Gallery Game tasks for a month. Assessments consisted of cross-modal paired-associate learning, with subsequent tests of recognition and free recall following delays ranging from one to 13 days.Results: Retention intervals of at least three days were needed to evidence significant forgetting at both recognition and paired-associate recall test. The association between Gallery Game outcomes and established in-clinic memory assessments were small but numerically in the anticipated direction. In addition, there was preliminary support for utilizing the perirhinal-dependent pattern of semantic false alarms during object recognition as a marker of early impairment.Conclusions: These results support the need for tests of longer-term memory to sensitively record behavioral differences in adults with no diagnosis of cognitive impairment. Aggregate behavioral outcomes promote Gallery Game's utility as a digital assessment of episodic memory, aligning with established theoretical models of object memory and showing small yet uniform associations with existing in-clinic tests. Initial support for the discriminatory value of perirhinal-targeted outcomes justifies ongoing large-sample validation against traditional biomarkers of Alzheimer's disease.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/94331
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