Engineering of Adult Neurogenesis and Gliogenesis.
- Berninger B Adult Neurogenesis and Cellular Reprogramming, Institute of Physiological Chemistry & Focus Program Translational Neuroscience, University Medical Center, Johannes Gutenberg University Mainz, 55128 Mainz, Germany.
- Jessberger S Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
- 2016-04-20
Published in:
- Cold Spring Harbor perspectives in biology. - 2016
English
Neural stem/progenitor cells (NSPCs) retain their ability to generate newborn neurons throughout life in the mammalian brain. Here, we describe how recently developed virus- and transgenesis-based techniques will help us (1) to understand the functional effects of neurogenesis in health and disease, (2) to design novel approaches to harness the potential for NSPC-associated endogenous repair, and (3) to induce the generation of neurons outside the main neurogenic niches in the adult brain.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1101/cshperspect.a018861
- PMID 27091941
- Persistent URL
- https://sonar.ch/global/documents/9460
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