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Regulation of LINE-1 in mammals
Journal article

Regulation of LINE-1 in mammals

  • Bodak, Maxime 1Swiss Federal Institute of Technology Zurich, Department of Biology, Institute of Molecular Health Sciences, Life Science Zurich Graduate School, Molecular Life Science Program, HPL G28, Otto-Stern-Weg 7, CH-8093 Zurich, Switzerland
  • Yu, Jian 2Swiss Federal Institute of Technology Zurich, Department of Biology, Institute of Molecular Health Sciences, Life Science Zurich Graduate School, Molecular and Translational Biomedecine Program, HPL G28, Otto-Stern-Weg 7, CH-8093 Zurich, Switzerland
  • Ciaudo, Constance 3Swiss Federal Institute of Technology Zurich, Department of Biology, Institute of Molecular Health Sciences, HPL G32.1, Otto-Stern-Weg 7, CH-8093 Zurich, Switzerland
Published in:
  • Biomolecular Concepts. - Walter de Gruyter GmbH. - 2014, vol. 5, no. 5, p. 409-428
General Biochemistry, Genetics and Molecular Biology
Cellular and Molecular Neuroscience
General Medicine
English AbstractTransposable elements (TEs) are mobile DNA elements that represent almost half of the human genome. Transposition of TEs has been implicated as a source of genome evolution and acquisition of new traits but also as an origin of diseases. The activity of these elements is therefore tightly regulated during the life cycle of each individual, and many recent discoveries involved the genetic and epigenetic mechanisms in their control. In this review, we present recent findings in this field of research, focusing on the case of one specific family of TEs: the long-interspersed nuclear elements-1 (LINE-1 or L1). LINE-1 elements are the most representative class of retrotransposons in mammalian genomes. We illustrate how these elements are conserved between mice and humans, and how they are regulated during the life cycle. Additionally, recent advances in genome-wide sequencing approaches allow us not only to better understand the regulation of LINE-1 but also highlight new issues specifically at the bioinformatics level. Therefore, we discuss the state of the art in analyzing such bioinformatics datasets to identify epigenetic regulators of repeated elements in the human genomes.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/94999
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