Journal article
Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement.
- Cazzaniga S Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
- Ballmer-Weber BK Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
- Gräni N Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
- Spring P Department of Dermatology, University Hospital of Lausanne CHUV, Lausanne, Switzerland.
- Bircher A Department of Dermatology, University Hospital Basel, Basel, Switzerland.
- Anliker M Clinic of Dermatology and Allergology, Cantonal Hospital St Gallen, St Gallen, Switzerland.
- Sonntag AK Department of Dermatology, Cantonal Hospital Aarau, Aarau, Switzerland.
- Piletta P Department of Dermatology, Geneva University Hospitals (HUG), Geneva, Switzerland.
- Huber C Department of Dermatology, Geneva University Hospitals (HUG), Geneva, Switzerland.
- Diepgen TL Department of Clinical Social Medicine, Occupational and Environmental Dermatology, University Hospital, Ruprecht Karls University, Heidelberg, Germany.
- Apfelbacher C Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
- Naldi L Centro Studio, Italian Group for Epidemiological Research in Dermatology (GISED), Bergamo, Italy.
- Borradori L Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
- Simon D Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
- 2018-06-27
Published in:
- Contact dermatitis. - 2018
CARPE
chronic hand eczema
clinical improvement
epidemiology
follow-up
quality of life
semantic map analysis
Chronic Disease
Dermatitis, Occupational
Eczema
Hand Dermatoses
Humans
Occupational Exposure
Prospective Studies
Quality of Life
Registries
Severity of Illness Index
Switzerland
English
BACKGROUND
Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce.
OBJECTIVE
To evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2 years.
METHODS
Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses.
RESULTS
Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified.
CONCLUSIONS
Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.
Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce.
OBJECTIVE
To evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2 years.
METHODS
Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses.
RESULTS
Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified.
CONCLUSIONS
Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1111/cod.13041
- PMID 29943397
- Persistent URL
- https://sonar.ch/global/documents/9585
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