Tandem Ring-Opening-Ring-Closing Metathesis for Functional Metathesis Catalysts.
- Nagarkar AA Department of Chemistry, University of Fribourg, Chemin du Musee 9, 1700, Fribourg, Switzerland.
- Yasir M Department of Chemistry, University of Fribourg, Chemin du Musee 9, 1700, Fribourg, Switzerland.
- Crochet A Department of Chemistry, University of Fribourg, Chemin du Musee 9, 1700, Fribourg, Switzerland.
- Fromm KM Department of Chemistry, University of Fribourg, Chemin du Musee 9, 1700, Fribourg, Switzerland.
- Kilbinger AF Department of Chemistry, University of Fribourg, Chemin du Musee 9, 1700, Fribourg, Switzerland. andreas.kilbinger@unifr.ch.
- 2016-09-06
Published in:
- Angewandte Chemie (International ed. in English). - 2016
English
Use of a tandem ring-opening-ring-closing metathesis (RORCM) strategy for the synthesis of functional metathesis catalysts is reported. Ring opening of 7-substituted norbornenes and subsequent ring-closing metathesis forming a thermodynamically stable 6-membered ring lead to a very efficient synthesis of new catalysts from commercially available Grubbs' catalysts. Hydroxy functionalized Grubbs' first- as well as third-generation catalysts have been synthesized. Mechanistic studies have been performed to elucidate the order of attack of the olefinic bonds. This strategy was also used to synthesize the ruthenium methylidene complex.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1002/anie.201604112
- PMID 27592840
- Persistent URL
- https://sonar.ch/global/documents/95866
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