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Follicular dendritic cells: origin, phenotype, and function in health and disease.
Journal article

Follicular dendritic cells: origin, phenotype, and function in health and disease.

  • Aguzzi A Institute of Neuropathology, University of Zurich, Zurich, Switzerland. Electronic address: adriano.aguzzi@usz.ch.
  • Kranich J Institute for Immunology, Ludwig Maximilians University, Munich, Germany.
  • Krautler NJ Garvan Institute of Medical Research, Darlinghurst, New South Wales, Sydney, Australia. Electronic address: n.krautler@garvan.org.au.
  • 2013-12-10
Published in:
  • Trends in immunology. - 2014
fibroblastic reticular cells
follicular dendritic cells
germinal center
lymphoid organogenesis
secondary lymphoid organs
tertiary lymphoid tissues
Animals
Dendritic Cells, Follicular
Humans
Phenotype
English Follicular dendritic cells (FDCs) were originally identified by their specific morphology and by their ability to trap immune-complexed antigen in B cell follicles. By virtue of the latter as well as the provision of chemokines, adhesion molecules, and trophic factors, FDCs participate in the shaping of B cell responses. Importantly, FDCs also supply tingible body macrophages (TBMs) with the eat-me-signaling molecule milk fat globule-EGF factor 8 (Mfge8), thereby enabling the disposal of apoptotic B cells. Recent studies have provided fundamental insights into the multiple functions of FDCs in both physiological and pathophysiological contexts and into their origin. Here we review these findings, and discuss current concepts related to FDC histogenesis both in lymphoid organs and in inflammatory lymphoneogenesis.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/96541
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