Efavirenz intoxication due to a new CYP2B6 constellation.
- Anagnostopoulos A Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.
- Rotger M
- Aouri M
- Kuster SP
- Telenti A
- Décosterd LA
- Günthard HF
- 2013-05-04
Published in:
- Antiviral therapy. - 2013
Adult
Alleles
Anti-HIV Agents
Aryl Hydrocarbon Hydroxylases
Benzoxazines
Cytochrome P-450 CYP2B6
Genotype
HIV Infections
HIV-1
Humans
Male
Pharmacogenetics
Polymorphism, Single Nucleotide
Reverse Transcriptase Inhibitors
English
Here, we describe severe neuropsychiatric symptoms in an HIV-positive Asian man with extremely high efavirenz plasma levels while receiving standard treatment with efavirenz/tenofovir/emtricitabine fixed-dose regimen. Genetic examination revealed compound homozygosity for loss-of-function alleles of CYP2B6, including coding for a rare truncated protein. Neuropsychiatric symptoms resolved completely after efavirenz discontinuation.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.3851/IMP2571
- PMID 23640958
- Persistent URL
- https://sonar.ch/global/documents/96607
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