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Carbon dioxide as the C1 source for direct C-H functionalization of aromatic heterocycles.
Journal article

Carbon dioxide as the C1 source for direct C-H functionalization of aromatic heterocycles.

  • Vechorkin O Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), SB-ISIC-LSCI, BCH 3305, Lausanne 1015, Switzerland.
  • Hirt N
  • Hu X
  • 2010-07-31
Published in:
  • Organic letters. - 2010
English A simple and straightforward method has been developed for the direct carboxylation of aromatic heterocycles such as oxazoles, thiazoles, and oxadiazoles using CO(2) as the C1 source. The reactions require no metal catalyst and only Cs(2)CO(3) as the base. A good functional group tolerance is achieved.
Language
  • English
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closed
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https://sonar.ch/global/documents/96896
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