Three-Component Reaction for the Synthesis of Highly Functionalized Propargyl Ethers.

Pisella G; Gagnebin A; Waser J

doi:10.1002/chem.202001317

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Journal article

Three-Component Reaction for the Synthesis of Highly Functionalized Propargyl Ethers.

Pisella G Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne, EPFL, SB ISIC LCSO, BCH 4306, 1015, Lausanne, Switzerland.
Gagnebin A Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne, EPFL, SB ISIC LCSO, BCH 4306, 1015, Lausanne, Switzerland.
Waser J Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne, EPFL, SB ISIC LCSO, BCH 4306, 1015, Lausanne, Switzerland.

2020-03-19

Published in:

Chemistry (Weinheim an der Bergstrasse, Germany). - 2020

multi-component reactions (MCR)

English Multicomponent reactions provide efficient means to access molecular complexity. Herein, we report a copper-catalyzed three-component reaction of diazo compounds, alcohols and ethynyl benziodoxole (EBX) reagents for the synthesis of propargyl ethers. Extensive variations of the three partners of the reaction is possible, leading to highly functionalized and structurally diverse products under mild conditions. Alkynylation of a copper ylide intermediate is postulated as key step for this transformation.

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