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Biogenesis of small nucleolar ribonucleoproteins.
Journal article

Biogenesis of small nucleolar ribonucleoproteins.

  • Filipowicz W Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland. Witold.Filipowicz@fmi.ch
  • Pogacić V
  • 2002-06-18
Published in:
  • Current opinion in cell biology. - 2002
Animals
Base Sequence
Brain
Cell Nucleolus
Coiled Bodies
Models, Genetic
Nuclear Proteins
RNA Processing, Post-Transcriptional
RNA, Small Nucleolar
Ribonucleoproteins
English Eukaryotic cells contain a very complex population of small nucleolar RNAs. They function, as small nucleolar ribonucleoproteins, in pre-ribosomal RNA processing reactions, and also guide methylation and pseudouridylation of ribosomal RNA, spliceosomal small nuclear RNAs, and possibly other cellular RNAs. Synthesis of small nucleolar RNAs frequently follows unusual strategies. Some newly discovered brain-specific small nucleolar RNAs of unknown function are encoded in introns of tandemly repeated units, expression of which is paternally imprinted. Recent studies of the protein components and factors participating in small nucleolar ribonucleoprotein assembly have revealed interesting connections with other classes of cellular ribonucleoproteins such as spliceosomal small nuclear ribonucleoproteins and telomerase. Cajal bodies emerge as nuclear structures important for the biogenesis and function of small nucleolar ribonucleoproteins.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/97483
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