Type III secretion: the bacteria-eukaryotic cell express.
- Mota LJ Biozentrum der Universität Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland.
- Sorg I
- Cornelis GR
- 2005-10-12
Published in:
- FEMS microbiology letters. - 2005
Animals
Bacterial Proteins
Eukaryotic Cells
Gene Expression Regulation, Bacterial
Gram-Negative Bacteria
Gram-Negative Bacterial Infections
Humans
Protein Transport
Virulence
English
Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell membrane of a translocation pore formed by T3S substrates; (iii) a non-cleavable N-terminal secretion signal; (iv) T3S chaperones, assisting the secretion of some substrates; (v) a control mechanism ensuring protein delivery at the right place and time. Here, we review these different aspects focusing in open questions that promise exciting findings in the near future.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/j.femsle.2005.08.036
- PMID 16216444
- Persistent URL
- https://sonar.ch/global/documents/97622
Statistics
Document views: 23
File downloads:
- Full-text: 0