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Journal article

Leucyl-tRNA synthetase: double duty in amino acid sensing.

  • Durán RV Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
  • Hall MN
  • 2012-04-25
Published in:
  • Cell research. - 2012
Animals
Energy Metabolism
Enzyme Activation
Humans
Leucine
Leucine-tRNA Ligase
Lysosomes
Mammals
Mechanistic Target of Rapamycin Complex 1
Multiprotein Complexes
Protein Interaction Mapping
Signal Transduction
TOR Serine-Threonine Kinases
Yeasts
English The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Two recent studies found that leucyl-tRNA synthetase (LRS) is a leucine sensor for TORC1, in both yeast and mammalian cells.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/97987
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