Journal article
Combined molecular lipophilicity descriptors and their role in understanding intramolecular effects.
- Caron G Institut de Chimie Thérapeutique, Section de Pharmacie, Université de Lausanne, CH-1015 Lausanne, Switzerland.
- Reymond F
- Carrupt PA
- Girault HH
- Testa B
- 1999-08-11
Published in:
- Pharmaceutical science & technology today. - 1999
English
Traditional lipophilicity parameters (log P and log D) are well-known physico-chemical descriptors largely used in QSAR studies. Besides their numerical value, log P data contain a variety of information about inter- and intramolecular forces affecting partitioning and its related biological phenomena. The deconvolution of information from log P can be accessed only by adequate interpretative tools, such as new lipophilic-combined descriptors, of which features and some applications are presented in this review.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/s1461-5347(99)00180-7
- PMID 10441277
- Persistent URL
- https://sonar.ch/global/documents/981
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