Migration and homeostasis of naive T cells depends on coronin 1-mediated prosurvival signals and not on coronin 1-dependent filamentous actin modulation.
- 2011-02-23
Published in:
- Journal of immunology (Baltimore, Md. : 1950). - 2011
Actins
Animals
Apoptosis Regulatory Proteins
CD4-Positive T-Lymphocytes
Calcineurin
Calcium Signaling
Cell Movement
Cell Survival
Homeostasis
Ligands
Mice
Mice, Inbred C57BL
Mice, Knockout
Microfilament Proteins
Receptors, Antigen, T-Cell
Resting Phase, Cell Cycle
English
Coronins are WD repeat-containing proteins highly conserved in the eukaryotic kingdom implicated in the regulation of F-actin. Mammalian coronin 1, one of the most conserved isoforms expressed in leukocytes, regulates survival of T cells, which has been suggested to be due to its role in preventing F-actin-induced apoptosis. In this study, we come to a different conclusion. We show that coronin 1 does not modulate F-actin and that induction of F-actin failed to induce apoptosis. Instead, coronin 1 was required for providing prosurvival signals, in the absence of which T cells rapidly underwent apoptosis. These results argue against a role for coronin 1 in F-actin-mediated T cell apoptosis and establish coronin 1 as an essential regulator of the balance between prosurvival and proapoptotic signals in naive T cells.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.4049/jimmunol.1003352
- PMID 21339362
- Persistent URL
- https://sonar.ch/global/documents/98265
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