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Journal article

Tenascins and the importance of adhesion modulation.

  • Chiquet-Ehrismann R Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland. ruth.chiquet@fmi.ch
  • Tucker RP
  • 2011-03-29
Published in:
  • Cold Spring Harbor perspectives in biology. - 2011
Animals
Cell Adhesion
Cell Movement
Evolution, Molecular
Gene Expression Regulation, Developmental
Humans
Mice
Neoplasm Invasiveness
Neoplasm Metastasis
Phylogeny
Signal Transduction
Tenascin
Transcription Factors
English Tenascins are a family of extracellular matrix proteins that evolved in early chordates. There are four family members: tenascin-X, tenascin-R, tenascin-W, and tenascin-C. Tenascin-X associates with type I collagen, and its absence can cause Ehlers-Danlos Syndrome. In contrast, tenascin-R is concentrated in perineuronal nets. The expression of tenascin-C and tenascin-W is developmentally regulated, and both are expressed during disease (e.g., both are associated with cancer stroma and tumor blood vessels). In addition, tenascin-C is highly induced by infections and inflammation. Accordingly, the tenascin-C knockout mouse has a reduced inflammatory response. All tenascins have the potential to modify cell adhesion either directly or through interaction with fibronectin, and cell-tenascin interactions typically lead to increased cell motility. In the case of tenascin-C, there is a correlation between elevated expression and increased metastasis in several types of tumors.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/98301
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