Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini.
- Keiser J Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. jennifer.keiser@unibas.ch
- Shu-Hua X
- Chollet J
- Tanner M
- Utzinger J
- 2006-12-30
Published in:
- Antimicrobial agents and chemotherapy. - 2007
Animals
Anthelmintics
Clonorchiasis
Clonorchis sinensis
Cricetinae
Fasciola hepatica
Fascioliasis
Female
Male
Mesocricetus
Mice
Opisthorchis
Phenylenediamines
Rats
Rats, Wistar
Schistosoma mansoni
Schistosomiasis mansoni
English
We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1128/AAC.01366-06
- PMID 17194822
- Persistent URL
- https://sonar.ch/global/documents/98311
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