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Journal article

Cytosolic Ca2+ buffers.

  • Schwaller B Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert-Gockel 1, CH-1700 Fribourg, Switzerland. beat.schwaller@unifr.ch
  • 2010-10-15
Published in:
  • Cold Spring Harbor perspectives in biology. - 2010
Animals
Buffers
Calbindin 1
Calbindin 2
Calbindins
Calcium
Calcium Signaling
Cations, Divalent
Cytosol
Homeostasis
Humans
Parvalbumins
S100 Calcium Binding Protein G
English "Ca(2+) buffers," a class of cytosolic Ca(2+)-binding proteins, act as modulators of short-lived intracellular Ca(2+) signals; they affect both the temporal and spatial aspects of these transient increases in [Ca(2+)](i). Examples of Ca(2+) buffers include parvalbumins (α and β isoforms), calbindin-D9k, calbindin-D28k, and calretinin. Besides their proven Ca(2+) buffer function, some might additionally have Ca(2+) sensor functions. Ca(2+) buffers have to be viewed as one of the components implicated in the precise regulation of Ca(2+) signaling and Ca(2+) homeostasis. Each cell is equipped with proteins, including Ca(2+) channels, transporters, and pumps that, together with the Ca(2+) buffers, shape the intracellular Ca(2+) signals. All of these molecules are not only functionally coupled, but their expression is likely to be regulated in a Ca(2+)-dependent manner to maintain normal Ca(2+) signaling, even in the absence or malfunctioning of one of the components.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/98346
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