Journal article
Combined evoked potentials as markers and predictors of disability in early multiple sclerosis.
- Schlaeger R Department of Neurology, University Hospital Basel, Switzerland.
- D'Souza M
- Schindler C
- Grize L
- Kappos L
- Fuhr P
- 2011-07-23
Published in:
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. - 2012
Adult
Disabled Persons
Early Diagnosis
Evoked Potentials, Motor
Female
Humans
Longitudinal Studies
Male
Middle Aged
Multiple Sclerosis
Predictive Value of Tests
Prospective Studies
Young Adult
English
OBJECTIVE
To prospectively assess combined evoked potentials (EP) as markers and predictors of the disease course of early MS over 3 years.
METHODS
Fifty patients in the early phase of relapsing remitting MS prospectively received visual, somatosensory and motor EP and EDSS assessments at baseline (T1) and at 6 months intervals during 3 years. Spearman rank correlation was used to determine the relationship between z-transformed EP-latencies (z-EPL) and EDSS. Multivariable linear regression was performed to predict EDSS at year 3 (T7) in function of z-EPL(T1). Validity of the models was assessed using group cross-validation.
RESULTS
At each of the seven points in time, EDSS correlated with the sum of z-EPL (0.64 ≤ rho ≤ 0.79, p<0.001). The change of the sum of z-EPL(T7-T1) correlated with the change of EDSS(T7-T1) (rho=0.51, p=0.001). EDSS(T7) as predicted by the sum of z-scores of EP latencies or by the number of pathological EP results at baseline correlated with the observed clinical values after 3 years (rho>0.70, p<0.001, for both measures).
CONCLUSIONS
Multimodal EPs correlate well with clinical disability in cross-sectional and longitudinal comparison in early MS and allow prediction of disease evolution over 3 years.
SIGNIFICANCE
EPs seem well suited as markers of the disease course in early MS in clinical trials and bear potential for supporting decision-finding in individual patients.
To prospectively assess combined evoked potentials (EP) as markers and predictors of the disease course of early MS over 3 years.
METHODS
Fifty patients in the early phase of relapsing remitting MS prospectively received visual, somatosensory and motor EP and EDSS assessments at baseline (T1) and at 6 months intervals during 3 years. Spearman rank correlation was used to determine the relationship between z-transformed EP-latencies (z-EPL) and EDSS. Multivariable linear regression was performed to predict EDSS at year 3 (T7) in function of z-EPL(T1). Validity of the models was assessed using group cross-validation.
RESULTS
At each of the seven points in time, EDSS correlated with the sum of z-EPL (0.64 ≤ rho ≤ 0.79, p<0.001). The change of the sum of z-EPL(T7-T1) correlated with the change of EDSS(T7-T1) (rho=0.51, p=0.001). EDSS(T7) as predicted by the sum of z-scores of EP latencies or by the number of pathological EP results at baseline correlated with the observed clinical values after 3 years (rho>0.70, p<0.001, for both measures).
CONCLUSIONS
Multimodal EPs correlate well with clinical disability in cross-sectional and longitudinal comparison in early MS and allow prediction of disease evolution over 3 years.
SIGNIFICANCE
EPs seem well suited as markers of the disease course in early MS in clinical trials and bear potential for supporting decision-finding in individual patients.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.clinph.2011.06.021
- PMID 21778106
- Persistent URL
- https://sonar.ch/global/documents/98386
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