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Journal article

Hypoventilation: a risk factor for milk alkali syndrome?

  • 2012-07-17
Published in:
  • BMJ case reports. - 2010
Aged
Analgesics, Opioid
Back Pain
Calcium Carbonate
Diagnosis, Differential
Dose-Response Relationship, Drug
Female
Humans
Hypercalcemia
Hypoventilation
Infusion Pumps
Injections, Spinal
Long-Term Care
Morphine
Osteoporosis, Postmenopausal
Risk Factors
Sodium Chloride Symporter Inhibitors
English A 67-year-old woman was admitted to the hospital due to progressive mental changes, nausea and vomiting after a dose increase of an intrathecal morphine pump. We found severe hypercalcaemia due to milk alkali syndrome (MAS). Her symptoms resolved quickly after normalisation of hypercalcaemia. Similar to the original and the modern versions of the syndrome, ingested carbonate was the main source of bicarbonate in our case. The main trigger was a morphine overdose with volume contraction due to vomiting and a further aggravation of chronic compensatory elevation of bicarbonate due to hypoventilation leading to MAS; thus, suggesting hypoventilation as a risk factor for MAS.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.ch/global/documents/98476
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