Journal article
Triggered release from liposomes through magnetic actuation of iron oxide nanoparticle containing membranes.
- Amstad E Laboratory for Surface Science and Technology, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland.
- Kohlbrecher J
- Müller E
- Schweizer T
- Textor M
- Reimhult E
- 2011-03-01
Published in:
- Nano letters. - 2011
Electromagnetic Fields
Ferric Compounds
Liposomes
Materials Testing
Membranes, Artificial
Nanocapsules
Permeability
Pharmaceutical Preparations
English
The ideal nanoscale drug delivery vehicle allows control over the released dose in space and time. We demonstrate that this can be achieved by stealth liposomes comprising self-assembled superparamagnetic iron oxide nanoparticles (NPs) individually stabilized with palmityl-nitroDOPA incorporated in the lipid membrane. Alternating magnetic fields were used to control timing and dose of repeatedly released cargo from such vesicles by locally heating the membrane, which changed its permeability without major effects on the environment.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/nl2001499
- PMID 21351741
- Persistent URL
- https://sonar.ch/global/documents/98873
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