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Calcium and inorganic phosphate secretion of rat ileum in vitro. Influence of uremia and 1,25 (OH)2D3 inhibition.
Journal article

Calcium and inorganic phosphate secretion of rat ileum in vitro. Influence of uremia and 1,25 (OH)2D3 inhibition.

  • 1988-01-01
Published in:
  • Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. - 1988
Animals
Calcitriol
Calcium
Etidronic Acid
Growth Plate
Ileum
In Vitro Techniques
Intestinal Absorption
Intestinal Mucosa
Kinetics
Male
Nephrectomy
Phosphates
Rats
Rats, Inbred Strains
Uremia
English The unidirectional ileal transport of calcium (Ca) and inorganic phosphorus (Pi) of rats was measured in vitro with the modified Ussing technique. Animal preparation included 5/6 nephrectomy and EHDP treatment. They were compared to controls as well as to 1,25 (OH)2D3 supplemented rats. The results show that the ileum is a secretory organ for Ca and Pi, the serosa to mucosa transport (Jsm) exceeds the mucosa to serosa transport (Jms). Ca and Pi transport in sm direction is 1,25 (OH)2D3 independent but exhibits a mutual strong correlation. Our observations together with published data are in favor of mainly paracellular, non electrogenic sm transport of both ions. However, the factor controlling sm transport of Ca and Pi remains unidentified. The mucosa to serosa transport (Jms) in the ileum is low for both ions. Ca ms is stimulated by 1,25 (OH)2D3, Pi ms is unchanged.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/98947
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