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Maternal Human Milk Oligosaccharide Profile Modulates the Impact of an Intervention with Iron and Galacto-Oligosaccharides in Kenyan Infants.

  • Paganini D Laboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland. daniela.paganini@uzh.ch.
  • Uyoga MA Laboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland. mary.uyoga@hest.ethz.ch.
  • Kortman GAM NIZO Food Research BV, 6718 ZB Ede, The Netherlands. Guus.Kortman@nizo.com.
  • Boekhorst J NIZO Food Research BV, 6718 ZB Ede, The Netherlands. Jos.Boekhorst@nizo.com.
  • Schneeberger S Department of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland. sacha.schneeberger@uzh.ch.
  • Karanja S Department of Medical Epidemiology, College of Health Sciences, Jomo Kenyatta University of Agriculture and Technology, 00200 Nairobi, Kenya. skaranja@jkuat.ac.ke.
  • Hennet T Department of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland. thierry.hennet@uzh.ch.
  • Zimmermann MB Laboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland. michael.zimmermann@hest.ethz.ch.
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  • 2019-11-02
Published in:
  • Nutrients. - 2019
Africa
Kenya
galacto-oligosaccharides
gut microbiota
human milk oligosaccharides
infant
iron
micronutrient powder
prebiotic
secretor
Adult
Bacteria
Dietary Supplements
Double-Blind Method
Female
Gastrointestinal Microbiome
Humans
Infant
Infant Nutritional Physiological Phenomena
Iron
Kenya
Male
Micronutrients
Milk, Human
Mothers
Oligosaccharides
RNA, Bacterial
RNA, Ribosomal, 16S
Young Adult
English There is little data on human milk oligosaccharide (HMO) composition in Sub-Saharan Africa. Iron fortificants adversely affect the infant gut microbiota, while co-provision of prebiotic galacto-oligosaccharides (GOS) mitigates most of the adverse effects. Whether variations in maternal HMO profile can influence the infant response to iron and/or GOS fortificants is unknown. The aim of this study was to determine HMO profiles and the secretor/non-secretor phenotype of lactating Kenyan mothers and investigate their effects on the maternal and infant gut microbiota, and on the infant response to a fortification intervention with 5 mg iron (2.5 mg as sodium iron ethylenediaminetetraacetate and 2.5 mg as ferrous fumarate) and 7.5 g GOS. We studied mother-infant pairs (n = 80) participating in a 4-month intervention trial in which the infants (aged 6.5-9.5 months) received daily a micronutrient powder without iron, with iron or with iron and GOS. We assessed: (1) maternal secretor status and HMO composition; (2) effects of secretor status on the maternal and infant gut microbiota in a cross-sectional analysis at baseline of the intervention trial; and (3) interactions between secretor status and intervention groups during the intervention trial on the infant gut microbiota, gut inflammation, iron status, growth and infectious morbidity. Secretor prevalence was 72% and HMOs differed between secretors and non-secretors and over time of lactation. Secretor status did not predict the baseline composition of the maternal and infant gut microbiota. There was a secretor-status-by-intervention-group interaction on Bifidobacterium (p = 0.021), Z-scores for length-for-age (p = 0.022) and weight-for-age (p = 0.018), and soluble transferrin receptor (p = 0.041). In the no iron group, longitudinal prevalence of diarrhea was higher among infants of non-secretors (23.8%) than of secretors (10.4%) (p = 0.001). In conclusion, HMO profile may modulate the infant gut microbiota response to fortificant iron; compared to infants of secretor mothers, infants of non-secretor mothers may be more vulnerable to the adverse effect of iron but also benefit more from the co-provision of GOS.
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  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/99076
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