A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue.
Journal article

A Needle-Type Microrobot for Targeted Drug Delivery by Affixing to a Microtissue.

  • Lee S Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
  • Kim JY Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
  • Kim J Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
  • Hoshiar AK School of Computer Science and Electronic Engineering, University of Essex, Colchester, CO4 3SQ, UK.
  • Park J Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
  • Lee S Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
  • Kim J School of Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do, 16419, South Korea.
  • Pané S Institute of Robotics and Intelligent Systems, ETH Zurich, Zurich, CH-8092, Switzerland.
  • Nelson BJ Institute of Robotics and Intelligent Systems, ETH Zurich, Zurich, CH-8092, Switzerland.
  • Choi H Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, Daegu-Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno jungang-daero, Hyeonpung-eup, Dalseong-Gun, Daegu, 42988, Republic of Korea.
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  • 2020-03-05
Published in:
  • Advanced healthcare materials. - 2020
English A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2 ) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s-1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/99219
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