Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.
- Bélanger M Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
- Allaman I
- Magistretti PJ
- 2011-12-14
Published in:
- Cell metabolism. - 2011
Astrocytes
Brain
Energy Metabolism
Glycogen
Lactic Acid
Models, Biological
Neurons
Oxidative Stress
Regional Blood Flow
English
The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes-a type of glial cell-have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a "neurocentric" view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.cmet.2011.08.016
- PMID 22152301
- Persistent URL
- https://sonar.ch/global/documents/99331
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