Journal article
Enantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones, dihydroisoquinolones and the BMS-791325 ring system.
- Pedroni J Laboratory of Asymmetric Catalysis and Synthesis , Institute of Chemical Sciences and Engineering , Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSA, BCH 4305 , CH-1015 Lausanne , Switzerland . Email: nicolai.cramer@epfl.ch.
- Saget T Laboratory of Asymmetric Catalysis and Synthesis , Institute of Chemical Sciences and Engineering , Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSA, BCH 4305 , CH-1015 Lausanne , Switzerland . Email: nicolai.cramer@epfl.ch.
- Donets PA Laboratory of Asymmetric Catalysis and Synthesis , Institute of Chemical Sciences and Engineering , Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSA, BCH 4305 , CH-1015 Lausanne , Switzerland . Email: nicolai.cramer@epfl.ch.
- Cramer N Laboratory of Asymmetric Catalysis and Synthesis , Institute of Chemical Sciences and Engineering , Ecole Polytechnique Fédérale de Lausanne , EPFL SB ISIC LCSA, BCH 4305 , CH-1015 Lausanne , Switzerland . Email: nicolai.cramer@epfl.ch.
- 2017-11-17
Published in:
- Chemical science. - 2015
English
Taddol-based phosphoramidite ligands enable enantioselective palladium(0)-catalyzed C-H arylation of cyclopropanes. The cyclized products are obtained in high yields and enantioselectivities. The reported method provides efficient access to a broad range of synthetically attractive cyclopropyl containing dihydroquinolones and dihydroisoquinolones as well as allows for an efficient enantioselective construction of the 7-membered ring of the cyclopropyl indolobenzazepine core of BMS-791325.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1039/c5sc01909e
- PMID 29142735
- Persistent URL
- https://sonar.ch/global/documents/99711
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