Journal article
Fulminant Lewy body disease.
- Momjian-Mayor I Department of Neurology, Geneva University Hospitals and Medical School, Geneva, Switzerland.
- Pizzolato GP
- Burkhardt K
- Landis T
- Coeytaux A
- Burkhard PR
- 2006-07-11
Published in:
- Movement disorders : official journal of the Movement Disorder Society. - 2006
14-3-3 Proteins
Aged
Brain
Creutzfeldt-Jakob Syndrome
Diagnosis, Differential
Disease Progression
Fatal Outcome
Humans
Lewy Bodies
Lewy Body Disease
Male
Neurologic Examination
Neuropsychological Tests
Parkinson Disease
English
The clinical distinction between Parkinson's disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB) is challenged by most neuropathological studies showing nearly identical changes in both conditions. We report an unusual case of PD evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly all clinical features of DLB. At autopsy, numerous Lewy bodies and Lewy neurites were found in several areas of the brainstem, the limbic system, and the neocortex, consistent with pure DLB. This case demonstrates that Lewy body disease may exhibit a dramatic course without any coexisting pathology and exemplifies that PD, PDD, and DLB may sometimes represent sequential, yet overlapping, phenotypes of a same clinicopathological entity.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1002/mds.21034
- PMID 16830307
- Persistent URL
- https://sonar.ch/global/documents/108437
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