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Notch and Neurogenesis.
Journal article

Notch and Neurogenesis.

  • Engler A Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Zhang R Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Taylor V Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel, Basel, Switzerland. verdon.taylor@unibas.ch.
  • 2018-07-22
Published in:
  • Advances in experimental medicine and biology. - 2018
Central nervous system
Dentate gyrus
Development
Hes
Maintenance
Neural stem cells
Neurogenesis
Notch
Rbpj
Subventricular zone
Animals
Brain
Embryo, Mammalian
Humans
Neural Stem Cells
Neurogenesis
Receptors, Notch
Regeneration
Signal Transduction
English Neurogenesis is the process of forming neurons and is essential during vertebrate development to produce most of the neurons of the adult brain. However, neurogenesis continues throughout life at distinct locations in the vertebrate brain. Neural stem cells (NSCs) are the origin of both embryonic and adult neurogenesis, but their activity and fate are tightly regulated by their local milieu or niche. In this chapter, we will discuss the role of Notch signaling in the control of neurogenesis and regeneration in the embryo and adult. Notch-dependence is a common feature among NSC populations, we will discuss how differences in Notch signaling might contribute to heterogeneity among adult NSCs. Understanding the fate of multiple NSC populations with distinct functions could be important for effective brain regeneration.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/111224
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