Journal article
E3 ubiquitin ligases and mitosis: embracing the complexity.
- 2008-01-25
Published in:
- Trends in cell biology. - 2008
English
Faithful division of eukaryotic cells requires temporal and spatial coordination of morphological transitions, which ensures that the newly replicated copies of the genome are equally distributed into the two daughter cells during mitosis. One of the mechanisms ensuring the fidelity of mitotic progression is targeted, ubiquitin-dependent proteolysis of key regulators. E3-ubiquitin ligase complexes are crucial components in this pathway because they specifically select the relevant ubiquitination substrates. Cullin-based E3-ligases, such as Cul3, have recently emerged as crucial regulators of mitosis.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.tcb.2007.12.001
- PMID 18215523
- Persistent URL
- https://sonar.ch/global/documents/111635
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