Mural thrombus of the aorta in association with homozygous plasminogen activator inhibitor type 1 (PAI-1)-675(4G) and heterozygous GP Ia 807C/T genotypes.

Beldi G; Bissat A; Eugster T; Gürke L; Stierli P; Huber AR

doi:10.1067/mva.2002.126549

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Journal article

Mural thrombus of the aorta in association with homozygous plasminogen activator inhibitor type 1 (PAI-1)-675(4G) and heterozygous GP Ia 807C/T genotypes.

Beldi G University Center for Vascular Surgery, Aarau/Basel, Switzerland. guido.beldi@ksa.ch
Bissat A
Eugster T
Gürke L
Stierli P
Huber AR

2002-09-10

Published in:

Journal of vascular surgery. - 2002

Genetic Predisposition to Disease

Plasminogen Activator Inhibitor 1

Platelet Membrane Glycoproteins

English Thrombus formation in the thoracic and abdominal aorta without evidence of arteriosclerotic disease is very uncommon. We present a case of a 50-year-old woman with a mural thrombus of the upper abdominal aorta associated with a combination of two mutations predisposing for thrombophilia. The genetic analysis showed a homozygous mutation of plasminogen activator inhibitor type 1 (PAI-1)-675 (4G) and a heterozygous mutation of GP Ia 807C/T. To our knowledge, this is the first report of the combination of both mutations occurring in a patient with isolated thrombus formation of the aorta.

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