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Validation of a Knowledge Transfer Tool for the Knee Inflammation MRI Scoring System for Bone Marrow Lesions According to the OMERACT Filter: Data from the Osteoarthritis Initiative.
Journal article

Validation of a Knowledge Transfer Tool for the Knee Inflammation MRI Scoring System for Bone Marrow Lesions According to the OMERACT Filter: Data from the Osteoarthritis Initiative.

  • Jaremko JL From the Department of Radiology and Diagnostic Imaging, and the Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland. jjaremko@ualberta.ca.
  • Azmat O From the Department of Radiology and Diagnostic Imaging, and the Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland.
  • Lambert RG From the Department of Radiology and Diagnostic Imaging, and the Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland.
  • Bird P From the Department of Radiology and Diagnostic Imaging, and the Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland.
  • Haugen IK From the Department of Radiology and Diagnostic Imaging, and the Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland.
  • Jans L From the Department of Radiology and Diagnostic Imaging, and the Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland.
  • Weber U From the Department of Radiology and Diagnostic Imaging, and the Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland.
  • Winn N From the Department of Radiology and Diagnostic Imaging, and the Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland.
  • Zubler V From the Department of Radiology and Diagnostic Imaging, and the Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland.
  • Maksymowych WP From the Department of Radiology and Diagnostic Imaging, and the Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Division of Medicine, University of New South Wales, Sydney, Australia; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium; King Christian 10th Hospital for Rheumatic Diseases, Gråsten; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland.
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  • 2017-04-03
Published in:
  • The Journal of rheumatology. - 2017
BONE MARROW LESION
KNEE JOINT
MRI
OMERACT
OSTEOARTHRITIS
SCORING METHODS
Aged
Bone Marrow
Female
Femur
Follow-Up Studies
Humans
Inflammation
Knee Joint
Magnetic Resonance Imaging
Male
Middle Aged
Osteoarthritis
Reproducibility of Results
Severity of Illness Index
Tibia
English OBJECTIVE
To assess feasibility and reliability of scoring bone marrow lesions (BML) on knee magnetic resonance imaging (MRI) in osteoarthritis using the Outcome Measures in Rheumatology Knee Inflammation MRI Scoring System (KIMRISS), with a Web-based interface and online training with real-time iterative calibration.


METHODS
Six readers new to the KIMRISS (3 radiologists, 3 rheumatologists) scored sagittal T2-weighted fat-saturated MRI in 20 subjects randomly selected from the Osteoarthritis Initiative data, at baseline and 1-year followup. In the KIMRISS, the reader moves a transparent overlay grid within a Web-based interface to fit bones, then clicks or touches each region containing BML per slice, to score 1 if BML is present. Regional and total scores are automatically calculated. Outcomes include the interreader intraclass correlation coefficients (ICC) and the smallest detectable change (SDC).


RESULTS
Scoring took 3-12 min per scan and all readers rated the process as moderately to very user friendly. Despite a low BML burden (average score 2.8% of maximum possible) and small changes, interobserver reliability was moderate to high for BML status and change in the femur and tibia (ICC 0.78-0.88). Four readers also scored the patella reliably, whereas 2 readers were outliers, likely because of image artifacts. SDC of 1.5-5.6 represented 0.7% of the maximum possible score.


CONCLUSION
We confirmed feasibility of knee BML scoring by new readers using interactive training and a Web-based touch-sensitive overlay system, finding high reliability and sensitivity to change. Further work will include adjustments to training materials regarding patellar scoring, and study in therapeutic trial datasets with higher burden of BML and larger changes.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/11621
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