Keratitis resulting from Thielavia subthermophila Mouchacca.

Theoulakis P; Goldblum D; Zimmerli S; Muehlethaler K; Frueh BE

doi:10.1097/ICO.0b013e31819717f4

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Journal article

Keratitis resulting from Thielavia subthermophila Mouchacca.

Theoulakis P Klinik und Poliklinik für Augenheilkunde, University of Bern, Inselspital, CH-3010 Bern, Switzerland. ptheoulakis@gmail.com
Goldblum D
Zimmerli S
Muehlethaler K
Frueh BE

2009-09-03

Published in:

Cornea. - 2009

English PURPOSE
The purpose of this study was to report the first case of fungal keratitis resulting from Thielavia sp.

METHODS
We conducted a retrospective chart review.

RESULTS
A 10-year old girl presented 2 weeks after ocular plant injury with pain and corneal stromal infiltration with central ulceration and ill-defined margins. Cultures of corneal scrapings and biopsy sequence analysis of the ribosomal internal transcribed spacer region isolated Thielavia subthermophila Mouchacca. Clinically, the organism appeared to respond to topical amphotericin B and oral voriconazole. Best-corrected visual acuity at last follow-up visit counted 0.5.

CONCLUSIONS
A rare case of Thielavia sp. keratitis was successfully treated with topical amphotericin B and oral voriconazole. Newly developed molecular diagnostic tools contribute to the recognition of a widening spectrum of emerging fungal pathogens capable of causing serious ocular infections.

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