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Dementia and subthalamic deep brain stimulation in Parkinson disease: A long-term overview.
Journal article

Dementia and subthalamic deep brain stimulation in Parkinson disease: A long-term overview.

  • Bove F From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Fraix V From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Cavallieri F From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Schmitt E From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Lhommée E From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Bichon A From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Meoni S From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Pélissier P From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Kistner A From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Chevrier E From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Ardouin C From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Limousin P From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Krack P From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Benabid AL From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Chabardès S From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Seigneuret E From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Castrioto A From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland.
  • Moro E From the Movement Disorders Unit (F.B., V.F., F.C., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.C., E.M.) and Neurosurgery Department (A.L.B., S.C., E.S.), CHU Grenoble Alpes, France; Institute of Neurology (F.B.), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Rome, Italy; U1216 (V.F., E.S., E.L., A.B., S.M., P.P., A.K., E.C., C.A., P.K., A.L.B., S.C., E.S., A.C., E.M.), Grenoble Institut des Neurosciences, Inserm, Université Grenoble Alpes, France; Neurology Unit (F.C.), Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia; Clinical and Experimental Medicine PhD Program (F.C.), University of Modena and Reggio Emilia, Modena; Department of Clinical and Movement Neurosciences (P.L.), University College London Queen Square Institute of Neurology, UK; and Department of Neurology (P.K.), INSELSPITAL, University Hospital Bern, Switzerland. elenamfmoro@gmail.com.
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  • 2020-07-03
Published in:
  • Neurology. - 2020
Adult
Aged
Deep Brain Stimulation
Dementia
Female
Humans
Incidence
Male
Middle Aged
Parkinson Disease
Prevalence
Subthalamic Nucleus
English OBJECTIVES
To assess the prevalence and the cumulative incidence of dementia at short-, medium- and long-term follow-up after deep brain stimulation (DBS) of the subthalamic nucleus (STN) (at 1, 5, and 10 years) and to evaluate potential risk factors for postoperative dementia.


METHODS
The presence of dementia (according to the DSM-V) was retrospectively evaluated at each postoperative follow-up in patients with Parkinson disease (PD) who underwent bilateral STN-DBS. Preoperative and perioperative risk factors of developing postoperative dementia were also investigated. Demographic data, disease features, medications, comorbidities, nonmotor symptoms, PD motor scales, neuropsychological scales at baseline, and perioperative complications were collected for each patient.


RESULTS
A total of 175 patients were included, and 104 were available at 10-year follow-up. Dementia prevalence was 2.3% at 1 year, 8.5% at 5 years, and 29.8% at 10 years. Dementia cumulative incidence at 1, 5, and 10 years was 2.3%, 10.9%, and 25.7%, respectively. The corresponding dementia incidence rate was 35.6 per 1,000 person-years. Male sex, higher age, hallucinations, lower frontal score at baseline, and perioperative cerebral hemorrhage were predictors of dementia.


CONCLUSIONS
In patients with PD with longstanding STN-DBS, dementia prevalence and incidence are not higher than those reported in the general PD population. Except for few patients with perioperative cerebral hemorrhage, STN-DBS is cognitively safe, and does not provide dementia risk factors in addition to those reported for PD itself. Identification of dementia predictors in this population may improve patient selection and information concerning the risk of poor cognitive outcome.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/122265
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