Glycosidase mechanisms.

Vasella A; Davies GJ; Böhm M

doi:10.1016/s1367-5931(02)00380-0

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Journal article

Glycosidase mechanisms.

Vasella A Laboratorium für Organische Chemie, ETH Hönggerberg, HCI H317, CH-8093 Zürich, Switzerland.
Davies GJ
Böhm M

2002-11-05

Published in:

Current opinion in chemical biology. - 2002

English The three-dimensional structure of glycosidases and of their complexes and the study of transition-state mimics reveal structural details that correlate with mechanism. Of particular interest are the transition-state conformations harnessed by individual enzymes and the substrate distortion observed in enzyme-ligand complexes. 3D-structure in synergy with transition-state mimicry opens the way for mechanistic interpretation of enzyme inhibition and for the development of therapeutic agents.

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